Glucose Metabolism
Fatty Acid Metabolism
Energy Metabolism
Inflammatory Cytokines
Inflammatory Response
Common Cytokines
Chemokines & Receptors
Autophagy
Mitochondria
Toll-Like Receptors
Oxidative Stress
Insulin Resistance
Lipoprotein & Cholesterol
Fatty Liver
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Mitochondrial DNA that escapes from autophagy leads to Toll-like receptor TLR-9-mediated inflammatory responses in cardiomyocytes and is able to induce myocarditis and dilated cardiomyopathy (Nature, May 2012)
FGF1 is highly induced in adipose tissue in response to a high-fat diet and mice lacking FGF1 develop an aggressive diabetic phenotype coupled to aberrant adipose expansion when challenged with a high-fat diet. Adipose induction of FGF1 in the fed state is regulated by PPARgamma acting through an evolutionarily conserved promoter proximal PPAR response element within the FGF1 gene. PPARgamma - FGF1 axis is critical for maintaining metabolic homeostasis and insulin sensitization (Nature, May 2012).
Review:
Lipid Autophagy
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