Прислали! Inflammation in Metabolism

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<small style="color: #000099;">          Inflammation in Metabolism </small>
 




 
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Glucose Metabolism

Fatty Acid Metabolism

Energy Metabolism

Inflammatory Cytokines

Inflammatory Response

Common Cytokines

Chemokines & Receptors

Autophagy

Mitochondria

Toll-Like Receptors

Oxidative Stress

Insulin Resistance

Lipoprotein & Cholesterol

Fatty Liver

Mitochondrial DNA that escapes from autophagy leads to Toll-like receptor TLR-9-mediated inflammatory responses in cardiomyocytes and is able to induce myocarditis and dilated cardiomyopathy (Nature, May 2012)

FGF1 is highly induced in adipose tissue in response to a high-fat diet and mice lacking FGF1 develop an aggressive diabetic phenotype coupled to aberrant adipose expansion when challenged with a high-fat diet.  Adipose induction of FGF1 in the fed state is regulated by PPARgamma acting through an evolutionarily conserved promoter proximal PPAR response element within the FGF1 gene. PPARgamma - FGF1 axis is critical for maintaining metabolic homeostasis and insulin sensitization (Nature,  May 2012).

Review:

Lipid Autophagy


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